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Dr. Ashay H. Nandeshwar
M. D., (Ayu)(Mumbai)
(Podar Govt. Medical College)
P.G.D.M.L.T., L.Lb. (Sch)
Lecturer V.P.A.M.C.
Sangli
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Treatment of Sickle cell Anaemia:
Aim: To inhibit the function of 11th gene in patient suffering from sickle cell disease.
Object: To reduce the crisis of patient suffering from sickle cell disease by using Ayurvedic medicines.
Summary: Very less literature is available about sickle cell anaemia, so far as anecdotal part of it is concerned.

What is sickle cell disease (S.C.D)?
Sickle cell disease may be a Heterozygous or a homozygous condition.
But more often it is homozygous condition. According to my studies S.C.D is
Homozygous: Heterozygous condition.

But the condition of Morphology of R.B.C varies with the ratio of SS: A2: F: A So if the Hemoglobin is totally of SS type then the R.B.C shows sickle shaped pattern but if the percentage of A2 i.e. Adult Hemoglobin and F i.e. Faetel Hemoglobin is more than the R.B.C shows Poikilocytosis and Anisocytosis conditions. R.B.C shows different shapes like hexagonal, polygonal, teardrop cells, pencil cells like structures.

We already know that valline is replaced by Glutamic Acid in S.C.D.

In SS: A2: F: A type the friability of R.B.C Outer layer is more so patients of this type require more blood transfusion.

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