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Dr. Ashay H. Nandeshwar
M. D., (Ayu)(Mumbai)
(Podar Govt. Medical College)
P.G.D.M.L.T., L.Lb. (Sch)
Lecturer V.P.A.M.C.
Sangli
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But in SS: F type of Hemoglobin, the irregular shaped R.B.C agglutinate and forms clamp which casuses ischemia and leads to crisis.

Signs & Symptoms of S.C.D patients:
 
  • In childhood they get rheumatoid arthritis like symptoms.
  • Sudden fall in Hemoglobin level.
  • Unbearable pain.
  • Involvement of multiple organs.
    a) Heapatic failure.
    b) Spleenic failure.
    C) Renal failure.
  • Due to frequent haemolysis increased billirubin level because of which icterus is cammon in S.C.D patients
  • Bone crush is the chronic condition of S.C.D
  • Necrosis of the joints specially hip joint and shoulder joints.
  • What is sickle cell trait?
    Sickle cell trait is a condition where the patient is Phenotypically normal and Genotypically abnormal.

    The allele shows S:A type of Hemoglobin.
    So though S.C.D is autosomal recessive disorder but I have seen in few casae the parents were normal but the children were showing S type of Hemoglobin.
    Treatment:
    In Allopathy there is no specific treatment, but when I started treatment with Ayurvedic medicines, we found the Morphological and Phenotypical changes in R.B.C and patient. The Blood Tranfusion and the crisis of the patients stopped.